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Table 3 Exosomes-based RNAs delivery for treating cancers

From: Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications

Tumor type

Exosome-based RNA delivery systems

Therapeutic results

Refs.

Glioblastoma multiforme

MSC-derived exosomes loaded with anti miR9

Reversing of chemoresistance of glioblastoma multiforme cells

[128]

Glioma

MSC-derived exosomes loaded with MiR146

Inhibition of glioma xenograft growth in glioma mice

[118]

Hepatocellular carcinoma

HLSCs-derived exosomes loaded with miRNA

Inhibition of the growth of hepatocellular carcinoma in mouse

[129]

Breast cancer

HEK293 cells-derived exosomes loaded with let-7a miRNA

Specific delivery of Let-7a miRNA to breast cancer tissue and strong inhibition of tumor growth

[72]

Breast tumor

Breast cells-derived exosomes loaded with HchrR6 mRNA

Inhibition of growth of HER2-positive human breast cancer

[71]

Glioma mouse model

Glioma cells-derived exosomes loaded with bEND mRNA

mRNA-loaded exosomes restored tumor-suppressor activity

[57]

U-87 Glioblastoma

bEND.3 cells-derived exosomes loaded with VEGF siRNA

Effective suppression of the aggregation of xeno-transplanted cancer cells; knockdown of VEGF in glioblastoma-astrocytoma cells

[68]

Mouse sarcomas

Mouse fibroblast L929 cells-derived exosomes loaded with TGF-β1 siRNA

Suppression of the growth and metastases of tumor in mice; strong inhibition of TGF-β1 expression

[130]

Breast cells

Endothelial exosomes loaded with siRNA against luciferase

Prevention of luciferase expression in the target cell

[131]

HeLa cells

HT1080 human fibrosarcoma/Hela cells-derived exosomes loaded with siRNA

Remarkable knockdown of the target protein

[76]

Pancreatic cancer

BM-MSC exosomes loaded with galectin-9 siRNA

effective innate and adaptive anti-PDAC immunotherapy upon disruption of galectin-9/dectin 1 axis

[132]

Colon cancer

HT-29 and SW480 derived exosomes loaded with miR-375-3p mimic

reverse epithelial mesenchymal transition (EMT) process of colon cancer cells

[133]