Skip to main content

Table 3 Exosomes-based RNAs delivery for treating cancers

From: Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications

Tumor type Exosome-based RNA delivery systems Therapeutic results Refs.
Glioblastoma multiforme MSC-derived exosomes loaded with anti miR9 Reversing of chemoresistance of glioblastoma multiforme cells [128]
Glioma MSC-derived exosomes loaded with MiR146 Inhibition of glioma xenograft growth in glioma mice [118]
Hepatocellular carcinoma HLSCs-derived exosomes loaded with miRNA Inhibition of the growth of hepatocellular carcinoma in mouse [129]
Breast cancer HEK293 cells-derived exosomes loaded with let-7a miRNA Specific delivery of Let-7a miRNA to breast cancer tissue and strong inhibition of tumor growth [72]
Breast tumor Breast cells-derived exosomes loaded with HchrR6 mRNA Inhibition of growth of HER2-positive human breast cancer [71]
Glioma mouse model Glioma cells-derived exosomes loaded with bEND mRNA mRNA-loaded exosomes restored tumor-suppressor activity [57]
U-87 Glioblastoma bEND.3 cells-derived exosomes loaded with VEGF siRNA Effective suppression of the aggregation of xeno-transplanted cancer cells; knockdown of VEGF in glioblastoma-astrocytoma cells [68]
Mouse sarcomas Mouse fibroblast L929 cells-derived exosomes loaded with TGF-β1 siRNA Suppression of the growth and metastases of tumor in mice; strong inhibition of TGF-β1 expression [130]
Breast cells Endothelial exosomes loaded with siRNA against luciferase Prevention of luciferase expression in the target cell [131]
HeLa cells HT1080 human fibrosarcoma/Hela cells-derived exosomes loaded with siRNA Remarkable knockdown of the target protein [76]
Pancreatic cancer BM-MSC exosomes loaded with galectin-9 siRNA effective innate and adaptive anti-PDAC immunotherapy upon disruption of galectin-9/dectin 1 axis [132]
Colon cancer HT-29 and SW480 derived exosomes loaded with miR-375-3p mimic reverse epithelial mesenchymal transition (EMT) process of colon cancer cells [133]