From: Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications
Tumor type | Exosome-based RNA delivery systems | Therapeutic results | Refs. |
---|---|---|---|
Glioblastoma multiforme | MSC-derived exosomes loaded with anti miR9 | Reversing of chemoresistance of glioblastoma multiforme cells | [128] |
Glioma | MSC-derived exosomes loaded with MiR146 | Inhibition of glioma xenograft growth in glioma mice | [118] |
Hepatocellular carcinoma | HLSCs-derived exosomes loaded with miRNA | Inhibition of the growth of hepatocellular carcinoma in mouse | [129] |
Breast cancer | HEK293 cells-derived exosomes loaded with let-7a miRNA | Specific delivery of Let-7a miRNA to breast cancer tissue and strong inhibition of tumor growth | [72] |
Breast tumor | Breast cells-derived exosomes loaded with HchrR6 mRNA | Inhibition of growth of HER2-positive human breast cancer | [71] |
Glioma mouse model | Glioma cells-derived exosomes loaded with bEND mRNA | mRNA-loaded exosomes restored tumor-suppressor activity | [57] |
U-87 Glioblastoma | bEND.3 cells-derived exosomes loaded with VEGF siRNA | Effective suppression of the aggregation of xeno-transplanted cancer cells; knockdown of VEGF in glioblastoma-astrocytoma cells | [68] |
Mouse sarcomas | Mouse fibroblast L929 cells-derived exosomes loaded with TGF-β1 siRNA | Suppression of the growth and metastases of tumor in mice; strong inhibition of TGF-β1 expression | [130] |
Breast cells | Endothelial exosomes loaded with siRNA against luciferase | Prevention of luciferase expression in the target cell | [131] |
HeLa cells | HT1080 human fibrosarcoma/Hela cells-derived exosomes loaded with siRNA | Remarkable knockdown of the target protein | [76] |
Pancreatic cancer | BM-MSC exosomes loaded with galectin-9 siRNA | effective innate and adaptive anti-PDAC immunotherapy upon disruption of galectin-9/dectin 1 axis | [132] |
Colon cancer | HT-29 and SW480 derived exosomes loaded with miR-375-3p mimic | reverse epithelial mesenchymal transition (EMT) process of colon cancer cells | [133] |