From: Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications
Neurological diseases | Exosome-based RNA delivery systems | Therapeutic results | Refs. |
---|---|---|---|
Huntington’s disease | HEK 293-cells derived exosomes loaded with MiR124 | Decrease in expression of the target gene; no improvement was recorded following exosomes treatment loaded with miR-124 | [89] |
Brain infarct | murine BM-MSCs-derived exosomes loaded with MiR124 | Protecting against ischemic injury through robust cortical neurogenesis; miRNA specific effect on the ischemic regions | [68] |
Morphine relapse | HEK 293Â T cells-derived exosomes loaded with MOR siRNA | Specific delivery of siRNA to the brain; down-regulation of the level of MOR protein and mRNA | [127] |
Alzheimer’s disease | mouse DC-derived exosomes loaded with siRNA | Knockdown of target mRNA and protein | [65] |