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Table 2 Exosome-based RNAs delivery for treating neurological diseases

From: Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications

Neurological diseases

Exosome-based RNA delivery systems

Therapeutic results

Refs.

Huntington’s disease

HEK 293-cells derived exosomes loaded with MiR124

Decrease in expression of the target gene; no improvement was recorded following exosomes treatment loaded with miR-124

[89]

Brain infarct

murine BM-MSCs-derived exosomes loaded with MiR124

Protecting against ischemic injury through robust cortical neurogenesis; miRNA specific effect on the ischemic regions

[68]

Morphine relapse

HEK 293 T cells-derived exosomes loaded with MOR siRNA

Specific delivery of siRNA to the brain; down-regulation of the level of MOR protein and mRNA

[127]

Alzheimer’s disease

mouse DC-derived exosomes loaded with siRNA

Knockdown of target mRNA and protein

[65]