Fig. 2
From: Identification of IGF1R mutation as a novel predictor of efficacious immunotherapy in melanoma
IGF1R mutation was associated with high TMB, DDR mutation and enhanced tumor immunity. A Comparison of the TMB between the IGF1R mutant and wildtype groups from WES cohorts. B Comparison of the TMB between the IGF1R mutant and wildtype groups from the MSKCC cohort. C Comparison of the TNB between the IGF1R mutant and wildtype groups from the WES cohorts. D Comparison of DNA damage-related gene set variants between IGF1R mutant and wildtype patients. E Bubble plot showing the enrichment of DNA repair- and oxidative phosphorylation-related pathways in IGF1R mutation patients relative to wildtype patients in advanced melanoma of WES cohorts. F DNA repair pathway. G Oxidative phosphorylation pathway