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Table 3 Association of adverse events and long-term participation in the study

From: Superior physical and mental health of healthy volunteers before and five years after mobilized stem cell donation

  Completer
n = 145
Non-completer
n = 97
All donors
n = 242
p-value
Any AE 88 (60.7%) 37 (38.1%) 125 (51.7%)  
  [52.2–68.7] [28.5–48.6] [45.2–58.1]  
Any serious AE 31 (21.4%) 7 (7.2%) 38 (15.7%) 0.089
  [15.0–29.0] [3.0–14.3] [11.4–20.9]  
AE related to G-CSF treatment 12 (8.3%) 2 (2.1%) 14 (5.8%) 0.228
  [4.3–14.0] [0.3–7.3] [3.2–9.5]  
Serious AE related to G-CSF treatment 3 (2.1%) 0 (0.0%) 3 (1.2%) 0.554
  [0.4–5.9] [0.0–3.7] [0.3–3.6]  
AE of special interest 2 (1.4%) 0 (0.0%) 2 (0.8%) 1.000
  [0.2–4.9] [0.0–3.7] [0.1–3.0]  
AE related to apheresis procedure 0 (0.0%) 1 (1.0%) 1 (0.4%) 0.296
  [0.0–2.5] [0.0–5.6] [0.0–2.3]  
  1. We hypothesized that adverse events in the post-mobilization period might negatively affect willingness to provide long-term follow-up. In order to address a possible connection we analyzed the occurrence of adverse events after the mobilization period in participants who complete 5 years and those who did not (using Fisher’s exact test). Donors experiencing any serious AE were, if anything, over-represented in the completer cohort (not statistically significant). Frequency is given in round brackets, interquartile range in square brackets. AE: adverse events, SAE: serious adverse events