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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Superior physical and mental health of healthy volunteers before and five years after mobilized stem cell donation

Fig. 1

Well-being over time as assessed with the SF-12 self-guided questionnaire. A Physical and mental well-being (Y-axis) over the phases of screening, apheresis and follow-up (X-axis) are displayed (mean, SD; for legibility, SD is drawn in only one direction). A dramatic transient dip in physical well-being is observed after mobilization with G-CSF, assessed just prior to the first apheresis, as well as a slow but steady decline of both physical and mental health scores is seen over time. B, C Age- (left) and sex-(right) adjusted physical and mental well-being of donors compared to a healthy cohort of German non-donors (published by Kuehne et al. [22]) at the time of donor screening (B) and at the five-year follow-up time point (C). D, E Age-adjusted physical and mental well-being of donors compared to a healthy cohort of German non-donors (published by Gandek et al.[23]) at the time of donor screening (D) and at the five-year follow-up time point (E). For both comparisons, donors were assigned to the respective age group based on their age at this specific time-point (i.e. at the time of donation, of 5-year follow-up). Of note, the Gandek cohort contains equal numbers of women and men, whereas our cohort is significantly skewed towards men who generally score higher on the SF-12 for both physical and mental health status. The data in panels BE show a markedly better than expected health status of HSPC donors compared to healthy non-donors of all age groups and for both sexes; the advantage is largely maintained over time. Throughout, physical and mental well-being are depicted as blue diamonds and red circles, respectively. Values for donors from our cohort are displayed as full symbols, those for the published reference groups as empty symbols. Asterisks indicate statistical significance at the ≤ 0.0001 (***), ≤ 0.001 (**), ≤ 0.01 (*) level, values between 0.01 and 0.05 are shown, n.s. (not significant) indicates a p > 0.05

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