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Table 5 Effect size of BRI on DM in prespecified and exploratory subgroups

From: Non-linear relationship between the body roundness index and incident type 2 diabetes in Japan: a secondary retrospective analysis

Characteristic

No. of participants

HR (95%CI)

P value

P for interacion

Gender

   

0.1092

 Female

6946

1.845 (1.461, 2.330)

< 0.001

 

 Male

8364

1.480 (1.254, 1.747)

< 0.001

 

SBP (mmHg)

0.9664

 < 140

14,569

1.591 (1.375, 1.842)

< 0.001

 

 ≥ 140

741

1.576 (1.024, 2.424)

0.0386

 

DBP (mmHg)

0.2317

 < 90

14,581

1.639 (1.411, 1.904)

 < 0.001

 

 ≥ 90

729

1.239 (0.801, 1.915)

0.3357

 

Smoking status

0.089

 Never-smoker

8928

1.826 (1.478, 2.255)

< 0.001

 

 Past-smoker

2938

1.196 (0.863, 1.658)

0.2821

 

 Current-smoker

3444

1.538 (1.234, 1.917)

0.001

 

Alcohol consumption

   

0.0634

 < 40

10,775

1.588 (1.318, 1.913)  < 0.0001

< 0.001

 

 ≥ 40,  < 140

2788

1.074 (0.744, 1.552) 0.7019

0.7019

 

 ≥ 140,  < 280

1360

0.879 (0.537, 1.439) 0.6072

0.6072

 

 ≥ 280

 ≥ 280

541

1.274 (0.670, 2.423) 0.4606

0.4606

 

Habit of exercise

0.1853

 No

12,614

1.529 (1.312, 1.781)

< 0.001

 

 Yes

2696

1.983 (1.387, 2.834)

0.0002

 

HDL-c (mmol/L)

0.1966

 < 1

1616

1.426 (1.109, 1.833)

0.0056

 

 ≥ 1

13,694

1.721 (1.467, 2.020)

< 0.0001

 

ALT (U/L)

0.5719

 ≤ 40

14,499

1.621 (1.388, 1.893)

< 0.0001

 

 > 40

811

1.464 (1.056, 2.029)

0.0221

 
  1. Above model adjusted age, gender, SBP, DBP, smoking status, ethanol consumption, habit of exercise, ALT, AST, GGT, FBG, HbA1c, HDL-c, TC, TG
  2. In each case, the model is not adjusted for the stratification variable
  3. ALT alanine aminotransferase; AST aspartate aminotransferase; CI confidence interval; DBP diastolic blood pressure; FBG fasting blood glucose; GGT glutamyl transpeptidase; HbA1c hemoglobin A1c; HDL-C high-density lipoprotein cholesterol; HR hazard ratio; Ref reference; SBP systolic blood pressure; TC total cholesterol; TG triglyceride