Non-linear relationship between the body roundness index and incident type 2 diabetes in Japan: a secondary retrospective analysis

Table 3 Relationship between BRI and the incident DM in different models

Variable	Crude model	Model I	Model II	GAM
Variable	(HR, 95%CI, P)	(HR, 95% CI, P)	(HR, 95% CI, P)	(HR, 95% CI, P)
BRI	2.662 (2.377, 2.981) < 0.001	2.285 (2.013, 2.595) < 0.001	1.570 (1.360, 1.811) < 0.001	1.555 (1.339, 1.806) < 0.001
BRI (quartile)
Q1	Ref.	Ref.	Ref.	Ref.
Q2	1.946 (1.191, 3.180) 0.007	1.569 (0.957, 2.572) 0.074	1.162 (0.704, 1.918) 0.557	1.251 (0.748, 2.089) 0.393
Q3	3.192 (2.028, 5.023) < 0.001	2.144 (1.348, 3.412) 0.001	1.057 (0.652, 1.713) 0.822	1.070 (0.650, 1.762) 0.789
Q4	9.385 (6.196, 14.216) < 0.001	5.421 (3.504, 8.387) < 0.001	1.892 (1.187, 3.017) 0.007	1.867 (1.150, 3.033) 0.011
P for trend	< 0.001	< 0.001	< 0.001	< 0.001

Crude model: we did not adjust other covariants
Model I: we adjust age, gender, SBP, DBP, smoking status, ethanol consumption, habit of exercise
Model II: we adjust age, gender, SBP, DBP, smoking status, ethanol consumption, habit of exercise, ALT, AST, FBG, HbA1c, HDL-c, TC, TG
GAM: All covariates listed in Model II were adjusted. However, continuous covariates were adjusted as non-linearity
ALT alanine aminotransferase; AST aspartate aminotransferase; CI confidence interval; DBP diastolic blood pressure; FBG fasting blood glucose; HbA1c hemoglobin A1c; HDL-C high-density lipoprotein cholesterol; HR hazard ratio; Ref reference; SBP systolic blood pressure; TC total cholesterol; TG triglyceride

ISSN: 1479-5876