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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Tumors carrying BRAF-mutations over-express NAMPT that is genetically amplified and possesses oncogenic properties

Fig. 6

NAMPT is genetically amplified in cancers, specifically in melanoma. A Scatter plot showing a positive correlation between NAMPT expression levels (Z score) and copy number alteration (CNA) SGOL scores across all TCGA samples for which paired CNA and expression values were present. R: Pearson coefficient, p: p-value. B Cumulative distribution function (cdf) plot of SGOL score for all coding genes on chr7 in primary (blue), metastatic (red) and matched blood-derived normal (black) samples from TCGA SKCM cohort. We can notice the shift toward left for the cdf of primary and metastatic derived samples respect to normal samples indicating amplification of the NAMPT gene. C Boxplot representing the quantification (n) and categorization of NAMPT SGOL scores from SKCM and control-matched samples

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