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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Tumors carrying BRAF-mutations over-express NAMPT that is genetically amplified and possesses oncogenic properties

Fig. 2

NAMPT protein levels are increased in BRAF-mutated vs. BRAF WT melanoma and thyroid carcinomas. A Dot plots representing NAMPT protein levels [H-score, defined by immunohistochemistry (IHC) staining] on tissue microarrays (TMAs) in metastatic melanoma (MM) grouped in BRAF WT, BRAF mutated (MUT), NRAS MUT and C-KIT MUT. N of samples in each group are indicated. Statistical significance was calculated using Mann–Whitney test. The line in the dot plot defines the median and the error bars define the interquartile range. Below the graphs, representative immunohistochemistry (IHC) stainings for NAMPT in BRAF WT, BRAF V600E, and NRAS Q61R MM cases. Scale bars are reported under the images. B Dot plot representing H-score of NAMPT protein levels on THCA whole slide sections grouped in BRAF WT and BRAF V600E. N of samples in each group are indicated. Statistical significance was calculated using Mann–Whitney test. The line in the dot plot defines the median and the error bars define the interquartile range. On the right, representative IHC staining for NAMPT in THCA cases. Scale bars are reported under images. Significance was represented as: *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001

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