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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Proton magnetic resonance spectroscopy detects cerebral metabolic derangement in a mouse model of brain coenzyme a deficiency

Fig. 2

Timeline of events extended from birth at postnatal day 1 (P1) through P45 when animals were anesthetized and midbrains were evaluated by magnetic resonance spectroscopy (MRS). Individual animals were identified and tail genotyping was performed at P5. Animals were assigned to three groups: SynCre+Pank1,2 dKO ± BBP-671 and SynCrePank1fl/fl,Pank2fl/fl matched wildtype controls, and were housed with control nursing dams at P14. Animals were maintained on the purified chow diet ± 75 ppm BBP-671 starting at P14 through P45, and weaned at P21. Mice were transferred to the Center for In Vivo Imaging and Therapeutics (CIVIT) at approximately P38 and MRS was performed at approximately P45. Numbers of mice in each group are indicated in parentheses

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