Derivation and validation of urinary TIMP-1 for the prediction of acute kidney injury and mortality in critically ill children

Table 3 Association of initial urinary TIMP-1 with AKI and PICU mortality in validation cohort

	AKI	Severe AKI	AKI stage 3	PICU mortality
OR^a (95% CI)	3.44 (2.50–4.74)	3.39 (2.44–4.72)	3.36 (2.34–4.83)	3.07 (2.19–4.31)
P value	< 0.001	< 0.001	< 0.001	< 0.001
AOR^a,b (95% CI)	2.88 (1.97–4.21)	2.62 (1.78–3.88)	2.94 (1.84–4.68)	1.92 (1.11–3.30)
P value	< 0.001	< 0.001	< 0.001	0.02
AUC (95% CI)	0.80 (0.74–0.86)	0.83 (0.77–0.89)	0.84 (0.77–0.92)	0.83 (0.76–0.89)
P value	< 0.001	< 0.001	< 0.001	< 0.001
Optimal cutoff, ng/mg uCr	4.88	5.58	11.79	11.79
Sensitivity, %	71.8	80.7	77.1	71.1
Specificity, %	78.9	78.7	84.2	84.0
PPV, %	77.2	79.1	83.0	81.6
NPV, %	73.7	80.3	78.6	74.4

Severe AKI was defined as KDIGO stage 2 or 3. Urinary TIMP-1 levels were log-transformed in the logistic regression because of the variation in the concentration
AKI acute kidney injury, AOR adjusted OR, AUC the area under the ROC curve, CI confidence interval, NPV negative predictive value, OR odds ratio, PICU pediatric intensive care unit, PPV positive predictive value, uCr urinary creatinine
^aOdds ratio represents the increase in risk per log increase in urinary TIMP-1 levels, ^bAdjustment for body weight, sex, PRISM III score, mechanical ventilation, sepsis, multi-organ dysfunction syndrome, and shock/disseminated intravascular coagulation

ISSN: 1479-5876