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Table 2 Univariate and multivariate linear regression analysis for clinical variables associated with initial urinary TIMP-1 level

From: Derivation and validation of urinary TIMP-1 for the prediction of acute kidney injury and mortality in critically ill children

  Univariate regressiona Multivariate regressionb
  B SE P value B SE P value value
Age, months 0.100 0.073 0.17 N/A   
Body weight, kg 0.139 0.161 0.39 N/A   
Sex − 0.116 0.100 0.25 N/A   
PRISM III score 0.052 0.005  < 0.001 0.031 0.006  < 0.001
AKI stage 0.489 0.041  < 0.001 0.377 0.049  < 0.001
MV 0.494 0.103  < 0.001 0.180 0.104 0.09
Sepsis 0.487 0.116  < 0.001 0.277 0.102 0.007
MODS 1.099 0.159  < 0.001 0.015 0.183 0.93
Shock/DIC 0.769 0.167  < 0.001 − 0.325 0.175 0.06
Antibiotic 0.116 0.121 0.34 N/A   
Inotrope 0.583 0.151  < 0.001 − 0.251 0.151 0.10
Furosemide 0.411 0.106  < 0.001 − 0.034 0.102 0.74
Steroid − 0.239 0.095 0.01 − 0.110 0.081 0.17
Hemofiltration 1.021 0.182  < 0.001 0.306 0.171 0.07
  1. AKI acute kidney injury, DIC disseminated intravascular coagulation, MODS multi-organ dysfunction syndrome, MV mechanical ventilation, N/A not applicable, PRISM III pediatric risk of mortality III. Continuous variables were log-transformed in the linear regression analyses
  2. aAll variables in Table 1 were analyzed in the univariate linear analysis
  3. bVariables with P < 0.05 were entered into the multivariate analysis after checking the multicollinearity by variance inflation factor and tolerance values