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Table 3 Incidence of chronic fatigue syndrome by age, sex and comorbidity and Cox model measured hazards ratio for patients with mycobacterium tuberculosis infection compared those without mycobacterium tuberculosis infection

From: How mycobacterium tuberculosis infection could lead to the increasing risks of chronic fatigue syndrome and the potential immunological effects: a population-based retrospective cohort study

Variables

Mycobacterium tuberculosis infection

Crude HR*

(95% CI)

Adjusted HR&

(95% CI)

No

Yes

Event

PY

Rate#

Event

PY

Rate#

Age, years

 ≤ 49

113

62,036

1.82

41

14,703

2.79

1.54 (1.08, 2.20)*

1.50 (1.05, 2.15)*

 ≥ 50

454

124,510

3.65

107

25,456

4.20

1.17 (0.95, 1.45)

1.15 (0.93, 1.42)

Sex

 Female

181

61,227

2.96

46

13,920

3.30

1.12 (0.81, 1.55)

1.14 (0.83, 1.58)

 Male

386

125,319

3.08

102

26,239

3.89

1.28 (1.03, 1.59)*

1.27 (1.02, 1.58)*

Comorbidity

 No

417

152,391

2.74

92

29,475

3.12

1.15 (0.92, 1.44)

1.18 (0.94, 1.48)

 Yes

150

34,155

4.39

56

10,684

5.24

1.20 (0.88, 1.63)

1.31 (0.96, 1.78)

Follow-up period

 < 1 years

72

30,136

2.39

22

7156

3.07

1.29 (0.80, 2.08)

1.26 (0.78, 2.04)

 > 1 years

495

156,410

3.16

126

33,002

3.82

1.21 (1.00, 1.48)*

1.22 (1.01, 1.49)*

  1. Rate#, incidence rate, per 1000 person-years; Crude HR *, relative hazard ratio; Adjusted HR: multivariable analysis including age, sex, and comorbidities of diabetes, renal disease, and inflammatory bowel disease;
  2. *p < 0.05, **p < 0.01, ***p < 0.001