Fig. 1

Differential DNA methylation distribution. A Circus plot of CpGs. Autosomal chromosomes are shown in a clockwise direction from 1 to 22 in the outermost circle. Red- and green-labeled genes correspond to the top 8 hypermethylated and hypomethylated genes, respectively. The two innermost circles represent the frequency of the filtered hypermethylated (inner) and hypomethylated (outer) CpG islets. The two middle circles show the histogram of p values of hypermethylated (inner) and hypomethylated (outer) CpG islets. The two outermost circles show the heatmaps with two different sample sets of methylated CpG islets. B Bar plot of differentially methylated CpGs throughout each genomic region. Body methylated CpG islets were excluded from further analysis. C Manhattan plot of epigenome-wide association results showing -log10 (P-value) labeled with the red line