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Table 1 Metabolites detected in the OV and OV_PTX groups using 1H-MRS

From: In vivo detection of dysregulated choline metabolism in paclitaxel-resistant ovarian cancers with proton magnetic resonance spectroscopy

Metabolites and ratios OV (n = 8) OV_PTX (n = 8) P value
Metabolite peaksa
 Ala 1 1
 Asp 1 0
 Ins 1 0
 Lac 1 2
 Tau 4 2 0.61
 GPC + PC 8 5 0.20
 NAA + NAAG 1 0
 Cr + PCr 8 6 0.47
 MM17 3 0
 Lip13a + Lip13b 5 7 0.57
 MM14 + Lip13a + Lip13b + MM12 5 7 0.57
 MM09 + Lip09 7 5 0.57
 MM20 + Lip20 3 5 0.62
Metabolite concentration ratios (/Cr + PCr)b
 GPC + PC 0.33 (0.10, 1.13) 1.64 (0.69, 4.18) 0.04
 Lip13a + Lip13b 11.48 (5.88, 18.28) 15.15 (9.96, 31.86) 0.43
 MM14 + Lip13a + Lip13b + MM12 12.95 (6.22, 20.42) 17.14 (12.15, 32.56) 0.43
 MM09 + Lip09 3.10 (0.84, 3.58) 4.65 (3.40, 9.92) 0.09
 MM20 + Lip20 3.28 (3.13, 5.56) 4.19 (2.75, 15.25) 0.46
  1. 1H-MRS proton-magnetic resonance spectroscopy, OV ovarian cancer, OV_PTX paclitaxel-resistant ovarian cancer, Ala alanine, Asp aspartate, Ins inositol, Lac lactate, Tau taurine, GPC + PC glycerophosphocholine + phosphocholine, NAA + NAAG N-acetylaspartate + N-acetylaspartatglutamate, Cr + PCr creatine + phosphocreatine, Lip lipids, MM macromolecules, the numbers after MM and Lip indicate the approximate chemical shift in ppm of the peaks: e.g., MM17: macromolecule peak near 1.7 ppm
  2. aChi-square test
  3. bMann–Whitney U test