Skip to main content

Table 1 Metabolites detected in the OV and OV_PTX groups using 1H-MRS

From: In vivo detection of dysregulated choline metabolism in paclitaxel-resistant ovarian cancers with proton magnetic resonance spectroscopy

Metabolites and ratios

OV (n = 8)

OV_PTX (n = 8)

P value

Metabolite peaksa

 Ala

1

1

–

 Asp

1

0

–

 Ins

1

0

–

 Lac

1

2

–

 Tau

4

2

0.61

 GPC + PC

8

5

0.20

 NAA + NAAG

1

0

–

 Cr + PCr

8

6

0.47

 MM17

3

0

–

 Lip13a + Lip13b

5

7

0.57

 MM14 + Lip13a + Lip13b + MM12

5

7

0.57

 MM09 + Lip09

7

5

0.57

 MM20 + Lip20

3

5

0.62

Metabolite concentration ratios (/Cr + PCr)b

 GPC + PC

0.33 (0.10, 1.13)

1.64 (0.69, 4.18)

0.04

 Lip13a + Lip13b

11.48 (5.88, 18.28)

15.15 (9.96, 31.86)

0.43

 MM14 + Lip13a + Lip13b + MM12

12.95 (6.22, 20.42)

17.14 (12.15, 32.56)

0.43

 MM09 + Lip09

3.10 (0.84, 3.58)

4.65 (3.40, 9.92)

0.09

 MM20 + Lip20

3.28 (3.13, 5.56)

4.19 (2.75, 15.25)

0.46

  1. 1H-MRS proton-magnetic resonance spectroscopy, OV ovarian cancer, OV_PTX paclitaxel-resistant ovarian cancer, Ala alanine, Asp aspartate, Ins inositol, Lac lactate, Tau taurine, GPC + PC glycerophosphocholine + phosphocholine, NAA + NAAG N-acetylaspartate + N-acetylaspartatglutamate, Cr + PCr creatine + phosphocreatine, Lip lipids, MM macromolecules, the numbers after MM and Lip indicate the approximate chemical shift in ppm of the peaks: e.g., MM17: macromolecule peak near 1.7 ppm
  2. aChi-square test
  3. bMann–Whitney U test