Fig. 1

UAP1L1 upregulated in prostate cancer tissues and promoted the proliferation and migration of prostate cancer cells. A The expression levels of UAP1L1 was upregulated in prostate cancer tissues, which was detected by immunohischemical staining. Magnification was 200 times and 400 times. B MTT assay results indicated that UAP1L1 knockdown inhibited the proliferation of prostate cancer cells (DU 145 and PC-3). C The colony number in shUAP1L1 group was significantly decreased according to the results of clone formation assay. D The migration ability of prostate cancer cells was determined by wound healing assay and the migration rate was reduced after UAP1L1 knockdown. E The invasion ability of prostate cancer cells was detected through Transwell assay. ShCtrl: prostate cancer cells infected with shRNA of control; shUAP1L1: prostate cancer cells infected with shRNA of UAP1L1. **P < 0.01; ***P < 0.001; ****P < 0.0001