Fig. 5From: Ligand-activated PPARδ expression promotes hepatocellular carcinoma progression by regulating the PI3K-AKT signaling pathwayPPARδ promoted HCC progression by regulating the PI3K-AKT signaling pathway in HCC cell (A). PPARδ agonist GW501516 increased the expression of p-PDK1 (B), AKT (C), p-AKT (D), p-GSK3β (E) and Cyclin D1 (F) in Bel 7402 and SMMC-7721 cell, the antagonist abolished the effect. Schematic diagram of the role of PPARδ/PDK1/AKT/GSK3β signaling pathway in HCC progression (G)Back to article page