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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Ligand-activated PPARδ expression promotes hepatocellular carcinoma progression by regulating the PI3K-AKT signaling pathway

Fig. 3

Effect of PPARδ on proliferation of HCC cell. PPARδ agonist GW501516 increased mRNA expression of PPARδ target gene Angptl4. while antagonist GSK3787 reversed its up-regulated expression (A, B). The CCK8 assay results revealed that the agonist promoted HCC cells proliferation in a dose-dependent manner (C, D) and GSK3787 reversed the proliferation effect of GW501516 (E, F). EdU staining assay results showed that the intervention of GW501516 increased the ratio of proliferating cells, and GSK3787 reversed the proliferation effect of GW501516 in Bel 7402 cell line (G, I) and SMMC-7721 cell line (H, J)

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