| |
Univariate
|
Multivariable
|
|---|
|
HR
|
95%CI
|
P
|
HR
|
95%CI
|
P
|
|---|
|
Age
|
1.09
|
1.08–1.1
|
< 0.001
|
1.05
|
1.038–1.063
|
< 0.001
|
|
Race
| | | | | | |
|
White
|
Reference
| | | | | |
|
Black
|
0.96
|
0.73–1.26
|
0.8
| | | |
|
Othera
|
0.93
|
0.68–1.27
|
0.6
| | | |
|
Sex
| | | | | | |
|
Male
|
Reference
| | | | | |
|
Female
|
1
|
0.84–1.18
|
0.9
| | | |
|
Year of diagnosis
| | | | | | |
|
2010–2013
|
Reference
| | | | | |
|
2014–2017
|
0.98
|
0.81–1.18
|
0.8
| | | |
|
Histologic type
| | | | | | |
|
Clear cell
|
Reference
| | |
Reference
| | |
|
Papillary
|
0.89
|
0.68–1.15
|
0.4
|
0.852
|
0.65–1.117
|
0.2
|
|
Chromophobe
|
0.6
|
0.36–0.97
|
0.038
|
0.517
|
0.314–0.851
|
0.009
|
|
Otherb
|
2.28
|
1.9–2.73
|
< 0.001
|
0.921
|
0.717–1.184
|
0.5
|
|
Laterality
| | | | | | |
|
Left
|
Reference
| | | | | |
|
Right
|
1.13
|
0.96–1.34
|
0.15
| | | |
|
T stage
|
1.69
|
1.55–1.84
|
< 0.001
|
1.831
|
1.661–2.018
|
< 0.001
|
|
Grade
| | | | | | |
|
I
|
Reference
| | |
Reference
| | |
|
II
|
1.62
|
1.07–2.45
|
0.022
|
1.744
|
1.148–2.65
|
0.009
|
|
III
|
2.07
|
1.34–3.19
|
0.001
|
2.155
|
1.379–3.368
|
0.001
|
|
IV
|
5.64
|
3.2–9.96
|
< 0.001
|
4.397
|
2.462–7.852
|
< 0.001
|
|
Unknown
|
3.99
|
2.66–5.97
|
< 0.001
|
1.777
|
1.15–2.746
|
0.01
|
|
Surgery
| | | | | | |
|
No
|
Reference
| | |
Reference
| | |
|
Local excisionc
|
0.25
|
0.19–0.33
|
< 0.001
|
0.403
|
0.297–0.547
|
< 0.001
|
|
Partial Nephrectomy
|
0.11
|
0.08–0.15
|
< 0.001
|
0.166
|
0.117–0.236
|
< 0.001
|
|
Radical Nephrectomy
|
0.3
|
0.25–0.36
|
< 0.001
|
0.26
|
0.194–0.349
|
< 0.001
|
|
Radiotherapy
| | | | | | |
|
No/unknown
|
Reference
| | |
Reference
| | |
|
Yes
|
5.9
|
2.94–11.87
|
< 0.001
|
2.554
|
1.254–5.2
|
0.01
|
|
Chemotherapy
| | | | | | |
|
No/unknown
|
Reference
| | | | | |
|
Yes
|
5.29
|
3.16–8.84
|
< 0.001
|
Reference
| | |
|
Tumors number
|
1.2
|
1.11–1.31
|
< 0.001
|
1.166
|
1.068–1.273
|
0.001
|
|
Marriage
| | | | | | |
|
No
|
Reference
| | | | | |
|
Married
|
0.67
|
0.56–0.79
|
< 0.001
| | | |
|
Tumor size
|
1.01
|
1–1.01
|
< 0.001
| | | |
- aOther includes Asian/Pacific Islander, American Indian/Alaskan Native
- bOthers includes the pathological type of RCC is not known
- cLocal excision includes cryosurgery, thermal ablation, laser excision
