Fig. 9From: RUNX3-mediated circDYRK1A inhibits glutamine metabolism in gastric cancer by up-regulating microRNA-889-3p-dependent FBXO4Graphical summary of mechanism of circDYRK1A in GC. RUNX3 enhances the expression of circDYRK1A, which in turn acts as a miR-889-3p sponge and upregulates FBXO4 expression, thus inhibiting glutamine metabolism and malignant phenotypes of GC cells to repress the progression of CGBack to article page