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Table 1 Circulating adiponectin levels and risk of nasopharyngeal carcinoma in retrospective and prospective cohorts

From: Adiponectin suppresses tumor growth of nasopharyngeal carcinoma through activating AMPK signaling pathway

 

Tertiles of total adiponectin levels, μg/mLa

 
 

< 1.34

1.35–7.07

≥ 7.08

Ptrend

Analysis 1: Retrospective follow-up, 2009–2015 (N = 284)b

 Total

    

  No. of cases

52

43

37

 

  No. of controls

40

55

57

 

  Model 1c

1.0 (ref)

0.60 (0.33–1.06)

0.49 (0.27–0.89)

0.020

  Model 2d

1.0 (ref)

0.76 (0.39–1.46)

0.67 (0.34–1.32)

0.248

 Male

    

  Model 1c

1.0 (ref)

0.62 (0.33–1.16)

0.45 (0.24–0.85)

0.014

  Model 3e

1.0 (ref)

0.71 (0.35–1.43)

0.53 (0.26–1.08)

0.082

 Female

    

  Model 1c

1.0 (ref)

0.46 (0.10–2.18)

1.25 (0.21–7.41)

0.335

  Model 3e

1.0 (ref)

0.88 (0.19–6.09)

2.41 (0.25–23.03)

0.445

Analysis 2: Prospective follow-up, 2008–2016 (N = 213)b

 Total

    

  No. of cases

28

25

18

 

  No. of controls

43

45

54

 

  Model 1c

1.0 (ref)

0.84 (0.42–1. 67)

0.48 (0.23–1.01)

0.142

  Model 2d

1.0 (ref)

1.04 (0.32–3.38)

0.26 (0.08–0.83)

0.023

 Male

    

  Model 1c

1.0 (ref)

0.86 (0.38–1.93)

0.28 (0.10–0.80)

0.018

  Model 3e

1.0 (ref)

0.39 (0.06–2.318

0.11 (0.01–0.70)

0.019

 Female

    

  Model 1c

1.0 (ref)

0.92 (0.25–3.34)

0.88 (0.27–2.89)

0.842

  Model 3e

1.0 (ref)

10.28 (0.59–179.22)

1.13 (0.18–6.88)

0.892

  1. aThe tertiles were defined based on distribution among all control subjects
  2. bORs and 95% CIs were estimated using unconditional logistic regression models in retrospective cohort, and conditional logistic regression models in prospective cohorts
  3. cModel 1 was unadjusted
  4. dModel 2 adjusted for gender, age, family history, EBV serology status and smoking
  5. eModel 3 adjusted for NPC family history, EBV serology status and smoking