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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: The POR rs10954732 polymorphism decreases susceptibility to hepatocellular carcinoma and hepsin as a prognostic biomarker correlated with immune infiltration based on proteomics

Fig. 4

Significantly decreased HPN expression in HCC and associated with worse prognosis. a Decreased protein abundance of HPN in HCC patients and an ROC curve of HPN for diagnosis of HCC in the discovery cohort. b Increased protein abundance of HPN with rs10954732 GA + AA genotypes in HCC patients. c Low expression of HPN conferring a poor prognosis in overall HCC patients in the discovery cohort. d Significantly altered OS between HPN high-expressing and low-expressing groups only in A allele carriers. e Patients with higher HPN levels were more likely to have lower AST, ALT, GGT and GLO. f Differential expression and ROC curve of HPN in adjacent tissues in HCC patients in TCGA database by comparison with normal subjects in the GTEx database. g Levels of HPN expression in tumor tissues of different tumor types from the TCGA database in TIMER. Note: *P < 0.05, **P < 0.01, ***P < 0.001. HCC hepatocellular carcinoma, AST transaminase, ALT alanine aminotransferase, GGT γ-glutamyl transpeptadase, GLO globulin

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