Fig. 3

Proteomic mechanisms for POR rs10954732 polymorphisms to confer decreased susceptibility to HCC. a A total of 222 DEPs related to rs10954732 A allele compared with the GG genotype in HCC patients as shown in a heat map. GO enrichment analysis (b) and Volcano plot (c) for 222 DEPs with dysregulation related with A allele carriers. d Wayne figure shows 46 DEPs intersections between 222 A allele-related DEPs and 1342 HCC-related DEPs. e Heat map of 34 DEPs with protein changes showing the opposite direction in the HCC group and A allele carriers. f Expression profiles of the top eight significantly up-regulated and one down-regulated DEPs in peritumoral tissues of HCC. Data are shown as mean ± SEM, **P < 0.01, ***P < 0.001 vs Normal group by Mann–Whitney U test. DEPs differentially expressed proteins, HCC hepatocellular carcinoma