Fig. 1

An overview of the experimental design workflow. Illustration of the potential mechanism underlying the role of POR rs10954732 (G > A) polymorphisms in decreased HCC susceptibility and increased OS of HCC using label-free quantitative proteomic analysis. POR cytochrome P450 oxidoreductase, HCC hepatocellular carcinoma, OS overall survival time. A carriers refers to rs10954732 GA+AA genotypes; GG refers to wild type. DEPs differentially expressed proteins, HPN hepsin, AUC area under the ROC curves. Go enrichment for BP, assigning Gene Ontology (GO) terms to proteins, specifying involvement in biological processes (BP). Nor means normal group based on human liver samples. Con means control group based on HCC mouse model. RNA-seq RNA sequencing, HCC hepatocellular carcinoma, ELISA enzyme-linked immunosorbent assay, WB western blot, IHC immunohistochemistry