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Table 3 Top 20 targets of the binding score with triptolide

From: Targets preliminary screening for the fresh natural drug molecule based on Cosine-correlation and similarity-comparison of local network

  Name of the target Source
1 Proto-oncogene c-Fos TCMSP
2 Interleukin-6 [27]
3 Tumor necrosis factor TCMSP
4 Apoptosis regulator BAX [28]
5 Vascular endothelial growth factor A TCMSP
6 Apoptosis regulator Bcl-2 TCMSP
7 Caspase-3 TCMSP
8 Gamma-aminobutyric-acid receptor subunit alpha-4 [29]
9 NRH dehydrogenase [quinone] 2
10 Matrix metalloproteinase-9 Stitch
11 Glutamate receptor 2
12 Transcription factor AP-1 TCMSP
13 Transcription factor p65 TCMSP
14 Ig gamma-1 chain C region
15 Glucocorticoid receptor Stitch
16 Gamma-aminobutyric-acid receptor alpha-5 subunit
17 Neuronal acetylcholine receptor subunit alpha-2 [30]
18 Neuronal acetylcholine receptor subunit alpha-7
19 Gamma-aminobutyric-acid receptor alpha-3 subunit
20 Muscarinic acetylcholine receptor M2