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Table 3 Top 20 targets of the binding score with triptolide

From: Targets preliminary screening for the fresh natural drug molecule based on Cosine-correlation and similarity-comparison of local network

 

Name of the target

Source

1

Proto-oncogene c-Fos

TCMSP

2

Interleukin-6

[27]

3

Tumor necrosis factor

TCMSP

4

Apoptosis regulator BAX

[28]

5

Vascular endothelial growth factor A

TCMSP

6

Apoptosis regulator Bcl-2

TCMSP

7

Caspase-3

TCMSP

8

Gamma-aminobutyric-acid receptor subunit alpha-4

[29]

9

NRH dehydrogenase [quinone] 2

–

10

Matrix metalloproteinase-9

Stitch

11

Glutamate receptor 2

–

12

Transcription factor AP-1

TCMSP

13

Transcription factor p65

TCMSP

14

Ig gamma-1 chain C region

–

15

Glucocorticoid receptor

Stitch

16

Gamma-aminobutyric-acid receptor alpha-5 subunit

–

17

Neuronal acetylcholine receptor subunit alpha-2

[30]

18

Neuronal acetylcholine receptor subunit alpha-7

–

19

Gamma-aminobutyric-acid receptor alpha-3 subunit

–

20

Muscarinic acetylcholine receptor M2

–