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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: CENPF/CDK1 signaling pathway enhances the progression of adrenocortical carcinoma by regulating the G2/M-phase cell cycle

Fig. 7

The potential therapeutic strategies or available chemical drugs for the treatment of ACC. a Immune infiltration analysis of CENPFhigh (n = 6) and CENPFlow (n = 7) samples in ACC. The immune fraction (b) and PCA analysis (c) in ACC samples. d Screening the expression level between the five genes, including LAG3, CTLA4, HAVCR2, PD-1 and PD-L1, and CENPF in ACC. Correlation between CENPF expression and MSI (e) and TMB (f) in ACC. The horizontal axis represents the gene expression distribution, and the vertical axis denotes the expression distribution of the TMB/MSI score. The density curve on the right side represents the distribution trend of the TMB/MSI score; The density curve of the upper part represents the distribution trend of genes; The value represents the correlation p-value, correlation coefficient, and calculation method. g The gene-drug interaction network of CENPF and related chemotherapeutics. Red arrows: chemotherapeutics up-regulate CENPF expression; green arrows: chemotherapeutics down-regulate CENPF expression. The numbers of arrows between the chemotherapeutics and CENPF in this network denote the supported numbers of previous literature

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