Fig. 5
CENPF regulates the cell cycle by interacting with CDK1, E2F1, and CCNB1 in ACC. a GSEA analysis of the KEGG pathway showed that cell cycle, DNA replication, nucleotide excision repair, and p53 signaling pathway were overtly involved in ACC with CENPFhigh. b GSEA analysis of Biocarta pathway and Hallmark description suggested that overexpressed CENPF was positively related to cell cycle (especially G2-phase of mitosis), G2/M checkpoint, and E2F targets. c Venn’s graph demonstrated that 20 genes, including CDK1, E2F1, and CCNB1, were overlapped in at least two groups. d Top 10 GSEA analysis of GO terms. e Correlation analysis between CDK1, CCNB1, E2F1, and CENPF expression in ACC. f Expression of CDK1 and E2F1 in ACC and normal samples. g Survival analysis of CDK1, CCNB1, and E2F1 in ACC based on GEPIA database. h PPI network figured out the close interactions among CENPF, CDK1, and CCNB1