Fig. 5
mPRα knockdown decreases hypoxia-induced HIF1α/VEGF content and LUAD cell aggressiveness A549 and PC-9 cells were transfected with si-mPRα or si-NC, exposed to hypoxia (1% O2) or normoxia (20% O2), and examined for A the protein levels of HIF1α and VEGF by Immunoblotting; B VEGF concentrations by ELISA; C, D cell migration and invasion by Transwell assays; E cell migration by wound healing assay. *P < 0.05, **P < 0.01, compared to 20% O2 si-NC; ##P < 0.01, compared to 20% O2 + si-mPRα; &&P < 0.01, compared to 1% O2 si-NC group