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Table 3 Association between TXNIP cg19693031 methylation and fasting blood glucose stratified by GLUT1 rs841853 genotypes

From: Interaction between a diabetes-related methylation site (TXNIP cg19693031) and variant (GLUT1 rs841853) on fasting blood glucose levels among non-diabetics

  rs841853-CC rs841853-CA + AA
β p-value β p-value
TXNIP cg19693031 (ref: ≥ Q3)
 Q2–Q3 0.8082 0.255 − 1.1672 0.160
 Q1–Q2 1.6930 0.022 0.0322 0.969
 < Q1 2.2190 0.004 0.1037 0.905
P for trend   0.002   0.491
Sex (ref: Women)
 Men 2.5831  < .001 2.2765 0.001
Age 0.1863  < .001 0.1980  < .001
  1. TXNIP thioredoxin-interacting protein, GLUT1 glucose transporter 1, β beta coefficient, ref reference
  2. Adjusted for body mass index, cigarette smoking, alcohol drinking, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, hypertension, regular exercise, vegetarian diet, and coffee and tea intake