Fig. 1
Tumor growth kinetics in C57BL/6 mice inoculated with different numbers of B16F10 cells. a Tumor growth curves after inoculation with optimal and suboptimal numbers of B16F10 cells. b, c Proportion of tumor-free and tumor-bearing mice following inoculation with B16F10 cells. Data pooled from n = 8 (1 × 105 cells per mouse, red), n = 12 (1 × 104 cells per mouse, dark blue), n = 29 (5 × 103 cells per mouse, blue) and n = 14 (2 × 103 cells per mouse, light blue) biologically independent experiments with n = 37 mice (1 × 105 cells per mouse), n = 54 mice (1 × 104 cells per mouse), n = 131 mice (5 × 103 cells per mouse) and n = 60 mice (2 × 103 cells per mouse). ****P < 10–10, log-rank Mantel-Cox test (b)