Methotrexate-loaded nanoparticles ameliorate experimental model of autoimmune arthritis by regulating the balance of interleukin-17-producing T cells and regulatory T cells

Table 1 Complete blood count of mice which were subcutaneously injected with vehicle, free MTX or MTX NPs

	Normal range	Vehicle	Free MTX	MTX NPs
WBC (K/μL)	1.8–10.7	4.38 ± 1.81	5.27 ± 0.39	4.65 ± 1.59
NE (K/μL)	0.1–2.4	0.47 ± 0.23	0.79 ± 0.07	0.62 ± 0.06
LY (K/μL)	0.9–9.3	3.72 ± 1.47	4.29 ± 0.37	3.79 ± 1.4
MO (K/μL)	0.0–0.4	0.16 ± 0.09	0.16 ± 0.02	0.22 ± 0.14
EO (K/μL)	0.0–0.2	0.023 ± 0.015	0.017 ± 0.006	0.017 ± 0.015
BA (K/μL)	0.0–0.2	0.003 ± 0.006	0 ± 0	0.003 ± 0.006
NE (%)	6.6–38.9	10.51 ± 0.82	15.12 ± 0.73	14.03 ± 3.49
LY (%)	55.8–91.6	85.37 ± 1.71	81.39 ± 1.09	81.01 ± 3.37
MO (%)	0.0–7.5	3.55 ± 0.7	3.14 ± 0.73	4.55 ± 1.67
EO (%)	0.0–3.9	0.48 ± 0.23	0.3 ± 0.07	0.34 ± 0.21
BA (%)	0.0–2.0	0.08 ± 0.02	0.63 ± 0.01	0.077 ± 0.09
RBC (M/μL)	6.36–9.42	7.47 ± 0.57	7.67 ± 0.7	7.21 ± 0.33
Hb (g/dL)	11.0–15.1	12.17 ± 0.64	12.2 ± 0.89	12.17 ± 0.65
PLT (K/μL)	592–2972	776 ± 307	757.3 ± 223	792.7 ± 87.51
MPV (fL)	5.0–20.0	3.73 ± 0.06	3.77 ± 0.06	3.8 ± 0.17

WBC white blood cell (K/μL, 10³ cells/μL), NE Neutrophil, LY lymphocyte, MO monocyte, EO eosinophil, BA basophil, RBC red blood cell (M/μL, 10⁶ cells/μL), Hb hemoglobin, PLT platelet, MPV mean platelet volume (mean ± S.D., n = 3)

ISSN: 1479-5876