Table 1 Demographics and clinicopathological features of LGG patients in all cohorts
TCGA | CGGA-mRNAseq_693 | CGGA-mRNAseq_325 | CGGA-mRNA-arry_301 | Rembrandt | |
|---|---|---|---|---|---|
Number of samples | 423 | 420 | 170 | 158 | 119 |
Age (mean ± SD; years) | 43.28 ± 13.34 | 40.32 ± 10.36 | 40.39 ± 10.85 | 39.58 ± 10.57 | NA |
Gender | |||||
Male | 234 | 235 | 105 | 90 | 59 |
Female | 189 | 185 | 65 | 68 | 37 |
NA | 0 | 0 | 0 | 0 | 23 |
Survival status | |||||
Alive | 317 | 223 | 82 | 85 | 34 |
Dead | 106 | 197 | 88 | 73 | 85 |
Pretreatment KPS | |||||
< 80 | 33 | NA | NA | NA | NA |
≥ 80 | 224 | NA | NA | NA | NA |
NA | 166 | NA | NA | NA | NA |
Histology | |||||
Astrocytoma | 154 | 254 | 110 | 102 | 80 |
Oligodendroglioma | 110 | 137 | 60 | 38 | 34 |
Oligoastrocytoma | 159 | 29 | 0 | 18 | 0 |
NA | 0 | 0 | 0 | 0 | 5 |
WHO grade | |||||
II | 201 | 172 | 97 | 105 | 63 |
III | 222 | 248 | 73 | 53 | 56 |
IDH status | |||||
Mutant | 344 | 288 | 125 | 104 | NA |
Wild type | 77 | 94 | 44 | 1 | NA |
NA | 2 | 38 | 1 | 53 | NA |
1p19q status | |||||
Codeletion | 141 | 125 | 55 | 16 | 8 |
Non-codeletion | 282 | 257 | 113 | 33 | 13 |
NA | 0 | 38 | 2 | 109 | 98 |
MGMT promoter status | |||||
Methylated | 351 | 200 | 84 | 43 | NA |
Unmethylated | 72 | 129 | 70 | 106 | NA |
NA | 0 | 91 | 16 | 9 | NA |
TERT status | |||||
Mutant | 120 | NA | NA | NA | NA |
Wild type | 140 | NA | NA | NA | NA |
NA | 163 | NA | NA | NA | NA |