Table 2 MiRNAs in cell proliferation, cell cycle, and apoptosis
MiRNAs | Samples | Cell functions | Target | Study |
|---|---|---|---|---|
miR-28-5p | GC tissues and adjacent normal tissues; GC cell lines:BGC823,SGC7901 | Inhibition of proliferation and migration of gastric cancer cells | AKT | [69] |
miR-7 | GC samples and matched non-GC samples; Cell lines: normal cell line(GES-1), GC cell lines(HEK-293 T,SGC-7901,BGC-823,HGC-27,MKN-28,MKN-40);Serum | Inhibition of GC metastasis; Suppress tumor development and angiogenesis of GC cells | NF-κB; Raf-1 | |
miR-181a | GC tissues and adjacent normal tissues; GC cell lines:MKN45,SGC-7901,MGC803,BGC-823,HEK-293Â T;Normal cell line:GES-1 | Inhibit apoptosis and promote the proliferation, invasion and metastasis of gastric cancer cells | Caprin-1 | [72] |
miR-1915 | 20 pairs of H. pylori-positive and negative gastritis tissues, 30 pairs of GC tissues and adjacent normal tissues; GC cell lines: SGC-7901, MKN-45;Normal cell line:GES-1 | Inhibits proliferation, invasion, and migration of Helicobacter pylori-Infected gastric cancer cells | RAGE | [73] |
miR-1299 | GC tissues and adjacent normal tissues; GC cell lines: AGS and SGC7901 | Inhibits cell proliferation, migration and invasion, and promotes cell apoptosis | ARF6 | [74] |
miR-133a-5p | GC tissues and adjacent normal tissues; GC cell lines: MGC-803, BGC-823, HGC-27, SGC-7901; Normal cell line:GES-1 | Inhibits cell growth and metastasis, and promotes apoptosis | TCF4 | [75] |
miR-653-5p | 80 pairs of GC tissues and adjacent normal tissues; GC cell lines: MGC803, BGC823, SGC7901, MKN45, AGS; Normal cell line:GES-1 | Promotes gastric cancer proliferation and metastasis | SOCS6-STAT3 | [76] |
miR-135b | de-identified 146 GC tissuesand 28 pairs of GC tissues; Blood samples from 23 GC patients and 27 health controls; GC cell lines: MKN28 and BGC823; Normal cell line:GES-1 | Promotes cell proliferation, migration and invasion | CAMK2D | [77] |
miR-30a-3p | GC cell lines: SGC7901, MGC803, and MGC823; Normal cell line:GES-1 | Inhibits the development of gastric cancer | APBB2 | [78] |
miR-1301-3p | GC and normal tissues from sixty patients; GC cell lines:MGC-803 and SGC-7901 | Promotes gastric cancer cell proliferation, cell cycle progression and tumorigenesis | SIRT1 | [79] |