Fig. 5
GeneSwitches analysis of scRNA-seq data from HSCs. A Visualization of the order of top fitting switching genes from various sets of known proteins along the pseudotime. The absolute value of the y-axis is the quality of fitting defined by McFadden's Pseudo R2, and the positive and negative signs indicate up- and down-regulation respectively. TFs, transcription factors. B Top 10 significantly changed pathways are plotted and ordered by the switching time. Ridge plots of pathways genes showing the density of switching genes. Numbers in parenthesis indicate the number of switching genes and total genes in the functional ontology respectively. C Visualization of the order of top fitting common switching genes between two paths along the pseudotime. D Visualization of top fitting distinct switching genes from the two paths along the pseudotime, i.e., genes that are only switching in one path and not the other.