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Table 1 Clinical characteristics of 10 SYSUCC patients with H3 G34-mutant diffuse hemispheric gliomas

From: High frequency of PDGFRA and MUC family gene mutations in diffuse hemispheric glioma, H3 G34-mutant: a glimmer of hope?

  Patient 1 Patient 2 Patient 3 Patient 4 Patient 5 Patient 6 Patient 7 Patient 8 Patient 9 Patient 10
Sex/age (years) F/14 F/18 M/16 F/20 M/25 F/23 F/23 M/13 F/21 M/21
Chef complaint Headache, nausea and vomiting Headache, nausea and vomiting Weakness of right limbs Generalized tonic clonic seizures Generalized tonic clonic seizures Headache, nausea and vomiting Headache and weakness of left limbs Dizziness and weakness of right foot Generalized tonic clonic seizures Weakness of left limbs
Site of lesion Left temporal lobe Right frontal lobe Left parietal lobe and corpus callosum Bilateral frontal lobe and corpus callosum Right frontal, temporal, insular lobe and basal ganglia Right frontal lobe, corona radiata, basal ganglia and corpus callosum Right frontal and insular lobe Left frontal and parietal lobe Left frontal lobe Right frontal and parietal lobe
Initial OP and adjuvant Tx GTR + CCRT + TMZ#12 GTR + CCRT + TMZ#2 STR + CCRT Biopsy + CCRT + TMZ#24 (continuously) GTR + CCRT + TMZ#22 (continuously) STR + CCRT STR + CCRT STR + CCRT + TMZ/DDP#4 + TMZ#6 GTR + CCRT + TMZ#3 GTR + Dianhydrodulcitol#12
2nd OP and adjuvant Tx GTR + RT + TMZ#12 NA Conservative NA NA Conservative Conservative Conservative STR + TG02#1 GTR
H3F3A G34R G34R G34V G34R G34R G34R G34R G34R G34R G34R
MGMT promoter Methylated Methylated Un-methylated Methylated Methylated Methylated Methylated Methylated Methylated Un-methylated
IDH Wildtype Wildtype Wildtype Wildtype Wildtype Wildtype Wildtype Wildtype Wildtype Wildtype
TERT promoter Wildtype Wildtype Wildtype Wildtype Wildtype Wildtype Wildtype Wildtype Wildtype Wildtype
Morphology GBM with primitive neuronal component GBM GBM GBM GBM GBM GBM GBM GBM GBM with primitive neuronal component
Current status Death Alive Death Alive Alive Death Alive Alive Death Alive
OS (months) 75 24 16 21 18 6 16 13 17 20
  1. CCRT concurrent chemotherapy and radiation therapy, DDP cisplatin, GBM glioblastoma, GTR gross total resection, MGMT O6-methylguanine-DNA methyltransferase, NA not applicable, RT radiation therapy, STR subtotal resection, TMZ temozolomide