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Fig. 9 | Journal of Translational Medicine

Fig. 9

From: piRNA-14633 promotes cervical cancer cell malignancy in a METTL14-dependent m6A RNA methylation manner

Fig. 9

piRNA-14633 contributed to tumorigenesis of Siha and Caski cells via METTL14/CYP1B1 axis. a and b Wound healing assay was used to analyze the migration capabilities of two cervical cancer cells transfected with 50 nM mi-14633 or co-transfected with 50 nM si-METTL14#1/2. Scale bars, 1000 μm. c and d Transwell assay was applied to measure migration abilities of Siha and Caski cells. Scale bars, 20 μm. e and f Transwell assay was applied to measure invasion abilities of Siha and Caski cells. g and h RT-PCR and Western blot waere used to analyze the expressions of CYP1B1 in two cervical cancer cells transfected with 50 nM mi-14633 or co-transfected with 50 nM si-METTL14#1/2. Scale bars, 20 μm. *P < 0.05 vs. mi-NC group. #P < 0.05 vs. mi-14633 + si-NC group. mi-14633 piRNA-14633 mimic, in-14633 piRNA-14633 inhibitor, si-NC siRNA-negtive control, si-METTL14#1/2 siRNA-METTL14#1/2

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