Fig. 4From: MAL protein suppresses the metastasis and invasion of GC cells by interfering with the phosphorylation of STAT3The MAL protein inhibits the EMT in GC cells. The RT–qPCR results showed that MAL silencing promoted the occurrence of the EMT in MGC-803 (A) and HGC-27 (B) GC cells, and MAL overexpression inhibited the EMT in MGC-803 (A) and HGC-27 (B) GC cells. MAL knockdown induced the occurrence of the EMT in MGC-803 (C) and HGC-27 cells (E), and MAL overexpression inhibited the EMT in MGC-803 (C) and HGC-27 (E) cells, as indicated by Western blotting. Statistical quantification of the expression of EMT-related proteins in the control group, MAL interference group and MAL overexpression group of MGC-803 (D) and HGC-27 (F) cells. The experiments were performed at least 3 times independently, and one representative result is shown. The results are presented as the means ± SD. *P < 0.05 and **P < 0.01Back to article page