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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: MAL protein suppresses the metastasis and invasion of GC cells by interfering with the phosphorylation of STAT3

Fig. 4

The MAL protein inhibits the EMT in GC cells. The RT–qPCR results showed that MAL silencing promoted the occurrence of the EMT in MGC-803 (A) and HGC-27 (B) GC cells, and MAL overexpression inhibited the EMT in MGC-803 (A) and HGC-27 (B) GC cells. MAL knockdown induced the occurrence of the EMT in MGC-803 (C) and HGC-27 cells (E), and MAL overexpression inhibited the EMT in MGC-803 (C) and HGC-27 (E) cells, as indicated by Western blotting. Statistical quantification of the expression of EMT-related proteins in the control group, MAL interference group and MAL overexpression group of MGC-803 (D) and HGC-27 (F) cells. The experiments were performed at least 3 times independently, and one representative result is shown. The results are presented as the means ± SD. *P < 0.05 and **P < 0.01

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