Fig. 9

The therapy effect of epigenetic drugs on HCC cells progression. A The impact of decitabine and CPI-455 on the proliferation of HCC cells was assessed by CCK8 assay respectively. B Decitabine increased the growth of already developed subcutaneous tumors. 3 mg/kg decitabine was administrated by intraperitoneal injection at day8, day10 and day12 into C57BL/6 J mice after implantation. C Decitabine decreased mouse body weight. D The overall survival of mice was significantly poor in decitabine treatment group relative to the controls. p is based on log-rank test. E MCM2 and NUP37 expression in tumors from decitabine or PBS group was analyzed by immunoblotting. Values represent the relative MCM2 or NUP37 expression levels compared to GAPDH