Fig. 4

MCM2 and NUP37 overexpression correlated with worse survival in HCC patients. A–B Box plots showing mRNA of MCM2 or NUP37 significantly correlates with the clinical stage of HCC. * p < 0.05, *** p < 0.001, based on Wilcoxon test. C–D Kaplan–Meier survival analysis was performed to assess the impact of MCM2 and NUP37 on survival of HCC patients from 3 independent cohorts. p is based on log-rank test. TCGA cohort (n = 370); NODE cohort (n = 150), and ZHE YI Cohort (n = 300). E–F Forest plots showing Cox univariate and multivariate survival analyses results in ZHE YI Cohort