Fig. 8
From: Subtyping of sarcomas based on pathway enrichment scores in bulk and single cell transcriptomes
Associations of the prognostic risk score (ICMScore) with the sarcoma subtypes and survival prognosis in sarcomas and other cancer types. A Comparisons of ICMScores among sarcoma subtypes. Kaplan–Meier curves showing that higher-ICMScore (> median) tumors have worse survival prognosis than lower-ICMScore (< median) tumors in sarcomas (B) and in six other cancer types (C). The log-rank test P-values are shown. ICMScore is a linear risk scoring model for evaluating the prognostic risk of sarcomas. It was developed based on the expression levels of five genes in five of the 14 pathways for clustering analysis, including T cell receptor signaling (CD40LG), cell cycle (CDC25A), mismatch repair (MSH2), focal adhesion (FLT4), and calcium signaling (ADCY2). OS, overall survival; DFS, disease-free survival; MFS, metastasis-free survival; ACC, adrenocortical carcinoma; KICH, kidney chromophobe; KIRC, kidney renal clear cell carcinoma; LGG, brain lower grade glioma; PRAD, prostate adenocarcinoma; SKCM, skin cutaneous melanoma