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Table 1 Experimental evidence of altered RBPs in OC

From: RNA-binding proteins in ovarian cancer: a novel avenue of their roles in diagnosis and treatment

Oncogenes
RBP Mechanism Putative targets Cellular phenotype References
Insulin-like growth factor 2 mRNA-Binding Protein IGF2BP1/IMP1 mRNA stability, Inhibiting decay c-MYC, MDR1, SRF Platinum,
Chemoresistance,
Growth,
invasion 		[101]
IGF2BP2/IMP2    Proliferation [90, 125]
IGF2BP3/IMP3 mRNA stability, mRNA translation HCTR1 Platinum,
Chemoresistance,
Proliferation,
Migration,
Invasion 		[70]
La-Related Protein 1 LARP1 mRNA stability, mRNA de-stability BIK, BCL2 Proliferation [67]
Lin28 Lin28A Alternative splicing, mRNA translation ROCK2 Invasion,
Metastasis,
Proliferation,
Migration,
Invasion 		[84]
LIN28B mRNA translation AKT2, NEAT1 Platinum Chemoresistance, Proliferation,
Migration,
Invasion 		[70]
Heterogeneous nuclear ribonucleoproteins (hnRNPs) hnRNPA2B1 mRNA stability Lin28B Proliferation,
Invasion,
Migration,
Apoptosis 		[69]
Hu family of RBPs (ELAV-like protein 1) HuR mRNA stability, mRNA translation TUBB3, lncRNA NEAT1, lncRNA MALAT1, lncRNA HOTAIR, ZEB2, TP53, E2F2 Proliferation,
Invasion,
Migration,
Paclitaxel resistance 		[60, 64, 91,92,93]
Y-box binding protein 1 YB1 mRNA stability, Translation modification   Chemotherapy resistance [106]
YT521-B homology (YTH) domain-containing proteins YTHDF1 mRNA translation EIF3C,
TRIM29 		Chemotherapy resistance [56, 126]
YTHDF2 mRNA translation BMF Proliferation,
Migration,
Invasion,
Apoptosis 		[58]
Polypyrimidine-tract binding protein-associated splicing factor SFPQ Alternative splicing Caspase-9 Apoptosis [70]
Forkhead box protein C2 FOXC2   GClnc1 EMT [95]
epithelial cell RBP ESRP1 Alternative splicing Circ-NOLC1 Prognosis [72]
Tumour suppressors
RNA-binding motif protein 3 RBM3 Translation BCL-2, BAX Platinum sensitivity [3, 77]
CUGBP and ETR-3-like family 2 CELF2 mRNA stability FAM198B Proliferation,
Migration,
Invasion 		[10]
Poly C Binding Protein 1 PCBP1 translational p27 Inhibiting OC progress [78]
heterogeneous nuclear family (hnRNPI) PTB Alternative splicing    [88]
Coiled-coil domain containing protein-124 Ccdc124    Prognosis [79]
Y-box binding protein 1 YBX1/YB1    Prognosis, resistance to cisplatin [106]
DEAD-Box Helicase 3X-Linked DDX3X Translation PHGDH   [80]
PAI-1 mRNA Binding Protein 1 PAI-RBP1   PAI-1 Progression [83]
Sorbin and SH3 domain-containing 2 SORBS2   WFDC1, IL-17D Cell migration, Metastatic [99]
RNA-binding motif protein 3 RBM3 DNA damage, Repair adverse cytotoxic effects after chemotherapy BCL-2, BAX, DNA integrity Prognosis, Platinum sensitivity [3, 77]
Quaking isoforms 5 QKI5 stability TAZ inhibit metastasis [100]
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Journal of Translational Medicine

ISSN: 1479-5876

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