RNA-binding proteins in ovarian cancer: a novel avenue of their roles in diagnosis and treatment

Wu, Jiangchun; Wu, Yong; Guo, Qinhao; Wang, Simin; Wu, Xiaohua

doi:10.1186/s12967-022-03245-6

Table 1 Experimental evidence of altered RBPs in OC

From: RNA-binding proteins in ovarian cancer: a novel avenue of their roles in diagnosis and treatment

Oncogenes
RBP		Mechanism	Putative targets	Cellular phenotype	References
Insulin-like growth factor 2 mRNA-Binding Protein	IGF2BP1/IMP1	mRNA stability, Inhibiting decay	c-MYC, MDR1, SRF	Platinum, Chemoresistance, Growth, invasion	[101]
	IGF2BP2/IMP2			Proliferation	[90, 125]
	IGF2BP3/IMP3	mRNA stability, mRNA translation	HCTR1	Platinum, Chemoresistance, Proliferation, Migration, Invasion	[70]
La-Related Protein 1	LARP1	mRNA stability, mRNA de-stability	BIK, BCL2	Proliferation	[67]
Lin28	Lin28A	Alternative splicing, mRNA translation	ROCK2	Invasion, Metastasis, Proliferation, Migration, Invasion	[84]
Lin28	LIN28B	mRNA translation	AKT2, NEAT1	Platinum Chemoresistance, Proliferation, Migration, Invasion	[70]
Heterogeneous nuclear ribonucleoproteins (hnRNPs)	hnRNPA2B1	mRNA stability	Lin28B	Proliferation, Invasion, Migration, Apoptosis	[69]
Hu family of RBPs (ELAV-like protein 1)	HuR	mRNA stability, mRNA translation	TUBB3, lncRNA NEAT1, lncRNA MALAT1, lncRNA HOTAIR, ZEB2, TP53, E2F2	Proliferation, Invasion, Migration, Paclitaxel resistance	[60, 64, 91,92,93]
Y-box binding protein 1	YB1	mRNA stability, Translation modification		Chemotherapy resistance	[106]
YT521-B homology (YTH) domain-containing proteins	YTHDF1	mRNA translation	EIF3C, TRIM29	Chemotherapy resistance	[56, 126]
YT521-B homology (YTH) domain-containing proteins	YTHDF2	mRNA translation	BMF	Proliferation, Migration, Invasion, Apoptosis	[58]
Polypyrimidine-tract binding protein-associated splicing factor	SFPQ	Alternative splicing	Caspase-9	Apoptosis	[70]
Forkhead box protein C2	FOXC2		GClnc1	EMT	[95]
epithelial cell RBP	ESRP1	Alternative splicing	Circ-NOLC1	Prognosis	[72]
Tumour suppressors
RNA-binding motif protein 3	RBM3	Translation	BCL-2, BAX	Platinum sensitivity	[3, 77]
CUGBP and ETR-3-like family 2	CELF2	mRNA stability	FAM198B	Proliferation, Migration, Invasion	[10]
Poly C Binding Protein 1	PCBP1	translational	p27	Inhibiting OC progress	[78]
heterogeneous nuclear family (hnRNPI)	PTB	Alternative splicing			[88]
Coiled-coil domain containing protein-124	Ccdc124			Prognosis	[79]
Y-box binding protein 1	YBX1/YB1			Prognosis, resistance to cisplatin	[106]
DEAD-Box Helicase 3X-Linked	DDX3X	Translation	PHGDH		[80]
PAI-1 mRNA Binding Protein 1	PAI-RBP1		PAI-1	Progression	[83]
Sorbin and SH3 domain-containing 2	SORBS2		WFDC1, IL-17D	Cell migration, Metastatic	[99]
RNA-binding motif protein 3	RBM3	DNA damage, Repair adverse cytotoxic effects after chemotherapy	BCL-2, BAX, DNA integrity	Prognosis, Platinum sensitivity	[3, 77]
Quaking isoforms 5	QKI5	stability	TAZ	inhibit metastasis	[100]

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