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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Circular RNA circCSPP1 promotes the occurrence and development of colon cancer by sponging miR-431 and regulating ROCK1 and ZEB1

Fig. 4

Knockdown of ROCK1 reverses the tumor-promoting effect of circCSPP1. Colon cancer cells were treated with pcDNA3.1-circCSPP1, pcDNA3.1-circCSPP1 plus miR-431 mimics or pcDNA3.1-circCSPP1 plus ROCK1 shRNA. A The expression of ROCK1 was detected with RT-qPCR. B CCK8 was used to detect the cell viability in each group. C Cell clone formation was used to assess the proliferation of clone cancer cells. D, E Cell migration and invasion were detected with transwell assays. **p < 0.01; n = 3

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Journal of Translational Medicine

ISSN: 1479-5876

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