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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Circular RNA circCSPP1 promotes the occurrence and development of colon cancer by sponging miR-431 and regulating ROCK1 and ZEB1

Fig. 1

CircCSPP1 is highly expressed in colon cancer tissues. A GEO database data analysis of colon cancer differentially expressed circRNA. B Wayne analysis of commonly differentially expressed circRNA in GSE121895 and GSE126094. C The expression of circRNAs in tumor tissues and in adjacent normal tissue was detected with RT-qPCR. D The expression of circCSPP1 in tumor tissues and in adjacent normal tissue was detected with RT-qPCR. E The expression of circCSPP1 in cell lines was tested with RT-qPCR. F The circRNA circularization mechanism is formed by splicing of exons 8 and 9, and sequencing confirmed the sequence is correct. G The localization of circCSPP1 in colon cancer cells was detected with FISH. H The expression of circCSPP1 in the nucleus and cytoplasm was detected by RT-qPCR. I The half-live of linear and circRNA were detected by RT-qPCR after actinomycin treatment. J The expression of linear and circRNA linear was detected with RT-qPCR after RNase R treatment. *p < 0.05 vs normal, **p < 0.01 vs normal, HFC, mock groups; n = 3

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Journal of Translational Medicine

ISSN: 1479-5876

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