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Table 3 Accuracy of ISOWN predictions

From: Incidental germline findings during molecular profiling of tumor tissues for precision oncology: molecular survey and methodological obstacles

Manual assignment

ISOWN

Germline

Somatic

Germline

TP = 436

FN = 42

Somatic

FP = 178

TN = 742

Variant of uncertain origin

87

46

Accuracy of ISOWN prediction: = 84.26%

Sensitivity: = 91.21%

Specificity: = 80.65%

Precision: = 71.01%