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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: GDF11 alleviates neointimal hyperplasia in a rat model of artery injury by regulating endothelial NLRP3 inflammasome activation and rapid re-endothelialization

Fig. 5

ER stress is involved in the activation of the NLRP3 inflammasome induced by upregulation of LOX-1 expression. A, B LysoPC increased the expression of proteins related to ER stress (GRP78 and CHOP). The ER stress inhibitor 4PBA (5 mM) inhibited LysoPC-induced ER stress-related proteins. C, D The ER stress inhibitor 4PBA inhibited NLRP3 inflammasome activation-related proteins (NLRP3, Casp1 p20, and IL-1β) and GSDMD-N expression. E, F GDF11 and si-LOX-1 pretreatment inhibited lysoPC-induced ER stress in human endothelial cells. * p < 0.05 vs. the control group; # p < 0.05 vs. the lysoPC group

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