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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: MiR-30c-5p loss-induced PELI1 accumulation regulates cell proliferation and migration via activating PI3K/AKT pathway in papillary thyroid carcinoma

Fig. 1

PELI1 is highly expressed in PTC tissues and cell lines. A StarBase v3.0 dataset (http://starbase.sysu.edu.cn/) showed that PELI1 was significantly upregulated in THCA tissues compared with normal tissues. B Correlation analysis of PELI1 and Ki-67 in THCA using starBase v3.0. C MRNA expression level of PELI1 in normal tissues, thyroid carcinoma tissues with no regional lymph node metastasis (N0) and thyroid carcinoma tissues with metastases in 1 to 3 axillary lymph nodes (N1) using the UALCAN dataset (http://ualcan.path.uab.edu/index.html). D Relative PELI1 expression levels in adjacent normal tissues and PTC tumor tissues were determined by Real-time PCR (n = 37). E, F Real-time PCR analysis showing the pattern of PELI1 expression in PTC tumor diameter ≥ 2 cm compared with tumor diameter < 2 cm (E), and metastatic PTC compared with non-metastatic PTC (F). G A representative images of IHC staining for PELI1 in human PTC tissues and adjacent non-tumor tissues (n = 10). The scale bars represent 100 µm (upper panel) and 50 µm (lower panel). H Western blotting analyses performed using human PTC tissues (T) and adjacent non-tumor tissues (N). Band intensities were normalized against the corresponding GAPDH and the numbers are presented as fold increase over the N group, respectively. I Nthy-ori 3–1, TPC-1 and W3 were analyzed for PELI1 expression using western blotting and a representative’s result was showed from two independent experiments. *P < 0.05, **P < 0.01

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