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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: FOXA1 can be modulated by HDAC3 in the progression of epithelial ovarian carcinoma

Fig. 4

HDAC3 affects FOXA1 and the Wnt/β-catenin signaling pathway. A Immunoblot and RT-PCR results show the expression of HDAC3 and FXOA1 in ovarian cancer cells after HDAC3 transfection. Lanes 1 and 5: mock groups in ES-2 and SKOV3 cells; lanes 2 and 6: HDAC3 high expression groups in ES-2 and SKOV3 cells; lanes 3 and 7: mock groups in ES-2 and SKOV3 cells; lanes 4 and 8: HDAC3 high expression groups in ES-2 and SKOV3 cells. Quantitative data are expressed as FOXA1 and HDAC3 relative to GAPDH. B Immunoblot results show the expression levels of β-catenin, cyclin D1, MMP2 and GAPDH in ES-2 and SKOV3 cells after HDAC3 transfection. Lanes 1 and 5, mock groups in ES-2 and SKOV3 cells; lane 2 and line 6, HDAC3 low expression group in ES-2 and SKOV3 cells; lanes 3 and 7, mock groups in ES-2 and SKOV3 cells; lane 4 and lane 8, HDAC3 high expression group. Quantitative data are expressed as β-catenin, cyclin D1 and MMP2 relative to GAPDH

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