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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: FOXA1 can be modulated by HDAC3 in the progression of epithelial ovarian carcinoma

Fig. 3

Effects of FOXA1 on OC cell proliferation capacity, apoptosis capacity and invasion capacity. A Immunoblot results show the expression of FOXA1 in ovarian cancer cells after FOXA1 transfection. Lanes 1 and 4: mock groups in ES-2 and SKOV3 cells; lanes 2 and 3: FOXA1 low expression groups in ES-2 and SKOV3 cells; lanes 5 and 8: mock groups in ES-2 and SKOV3 cells; lanes 6 and 7: FOXA1 high expression groups in ES-2 and SKOV3 cells. Quantitative data are expressed as FOXA1 relative to GAPDH. B RT-PCR results show that FOXA1 expression was increased in the FOXA1 overexpression group and decreased in the FOXA1 knockdown expression group in ES-2 and SKOV3 cells. C Cell colony forming results show that overexpression of FOXA1 significantly improved cell colony formation in ES-2 and SKOV3 cells, which was consistent with the EdU results (D, E). F Apoptosis assay results show that FOXA1 overexpression reduced OC cell apoptosis and that FOXA1 knockdown increased OC cell apoptosis. G Significantly greater invasion was observed in the FOXA1 overexpression group

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