|
Parameters
|
Baseline
|
End of phase 1
|
p value
|
|---|
|
Weight (kg)
|
94.38 ± 17.34
|
87.29 ± 15.99
|
< 0.001
|
|
BMI (kg/m2)
|
34.98 ± 5.43
|
32.35 ± 5.02
|
< 0.001
|
|
WC (cm)
|
106.16 ± 14.20)
|
99.24 ± 13.57
|
< 0.001
|
|
HC (cm)
|
120.53 ± 10.81
|
115.91 ± 9.70
|
< 0.001
|
|
WHR
|
0.88 ± 0.08
|
0.86 ± 0.09
|
< 0.001
|
|
Blood Glucose (mg/dL)
|
88.04 ± 8.95
|
82.60 ± 10.08
|
0.072
|
|
Insulin (mg/dL)
|
17.35 ± 13.83
|
8.05 ± 5.48
|
0.286
|
|
HOMA—IR
|
3.80 ± 2.79
|
1.74 ± 1.29
|
0.332
|
|
Tot Chol (mg/dL)
|
170.20 ± 40.77
|
144.72 ± 30.61
|
< 0.001
|
|
LDL Chol (mg/dL)
|
101.95 ± 29.11
|
81.40 ± 29.91
|
0.142
|
|
HDL Chol (mg/dL)
|
52.24 ± 12.17
|
49.86 ± 13.11
|
0.018
|
|
TG (mg/dL)
|
88.95 ± 30.77
|
86.14 ± 20.57
|
0.235
|
|
GFR (mL/min)
|
94.13 ± 19.00
|
89.00 ± 20.83
|
0.123
|
|
Creatinine (mg/dL)
|
0.77 ± 0.11
|
0.82 ± 0.16
|
< 0.001
|
|
Azotemia (mg/dL)
|
30.44 ± 8.94
|
34.89 ± 10.60
|
0.001
|
|
Uricemia (mg/dL)
|
5.29 ± 1.45
|
6.23 ± 1.69
|
0.054
|
|
AST (U/L)
|
20.50 ± 6.60
|
20.92 ± 6.32
|
0.022
|
|
ALT (U/L)
|
23.43 ± 9.85
|
22.90 ± 12.15
|
0.001
|
|
GGT (U/L)
|
17.82 ± 6.48
|
14.72 ± 5.25
|
0.003
|
|
Calcemia (mg/dL)
|
9.70 ± 0.75
|
9.90 ± 0.61
|
0.056
|
|
Sodiemia (mmol/L)
|
140.34 ± 2.72
|
140.53 ± 2.22
|
0.001
|
|
Potassiaemia (mmol/L)
|
4.41 ± 0.30
|
4.43 ± 0.33
|
0.452
|
- Data are expressed as n or mean ± SD
- BMI body mass index, WC waist circumference, HC hip circumference, WHR waist-to-hip-ratio, HOMA-IR homeostasis model of assessment-IR, Tot Chol total cholesterol, LDL-chol low-dense-lipoprotein cholesterol, HDL-chol high dense lipoprotein cholesterol, TG triglycerides, GFR glomerular filtration rate, AST aspartate aminotransferase, ALT alanine transaminase, GGT gamma-glutamyl transferase
