Fig. 1

Distinctions of the three receptors for chemerin. ChemR23, GPR1 and CCRL2 are cell-surface receptors, and all of them have a high affinity for chemerin. ChemR23 leads to strong signaling and internalization of the chemerin–receptor complex. GPR1 leads to weak signaling but also displays equal internalization as chemR23. CCRL2 does not signal nor internalizes but might pass on chemerin to functional chemR23 of nearby cells